By the end of this course, the students will be able to

1. Define basic concepts in Enzymology.

2. Describe mechanism of actions of enzymes

3. Describe kinetics of enzymatic reactions. 

4. Extrapolate importance of enzymes in clinical practice.

5. Enlist enzyme inhibitors and their importance.

Course overview

Metabolic biochemistry course taught to M. Phil Biochemistry students at Institute of Basic Medical Sciences, Khyber Medical Univeristy is divided into two first year courses: BMS – 719 and BMS – 720. These courses are designed to equip students with basic understanding of metabolic pathways and resulting diseases when normal metabolic processes are disrupted. BMS – 720 course more specifically focuses on biochemical pathways involved in metabolism of proteins, amino acids and nucleotides and diseases conditions resulting from abrogation of these metabolic pathways. The course consists of 10 blocks of lecture topics supplemented with self-assessment problem sets, questions/answers sessions and practice exams. Learning objectives, course materials and resources are provided online for each contact hour.

Learning outcomes

At the end of this course, the student will be able to

1.  Understand the basic concepts in Metabolism, Energy and Life.

2.  Differentiate between anabolic and catabolic pathways and their important enzymatic steps.

3. Extrapolate fundamental pathways involved in metabolism of proteins, amino acids and nucleotide.

4.   Extrapolate how these metabolic pathways are regulated during normal metabolic process.

5.   Make sense of how metabolic processes are disrupted during disease process.

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This course covers the basic metabolic pathways for the metabolism of carbohydrates and how they are regulated in the body in various physiological and pathological states. 

By the end of this course, the students should be able to 

  • Outline bioenergetics involved in oxidation-reduction reactions
  • Discuss the role of ATP as a central molecule in metabolism
  • Explain different kinds of modifications in substrates during metabolism
  • Discuss Glycolysis, Krebs cycle, Electron transport chain, gluconeogenesis, Glycogenesis and glycogenolysis
  • Explain how these pathways are regulated in the body during different physiological states such as exercise and during common pathologies such as diabetes